Antioxidant Support That Is Good for the Heart

Ubiquinol, the active antioxidant form of Coenzyme Q10 (CoQ10 or ubiquinone), is found throughout our cells, tissues, and organs. It is required for 95% of cellular energy (ATP) production1 and is essential for cellular function and antioxidant support, aiding physiological processes vital for cardiovascular health.

With age, our ubiquinol levels and antioxidant mechanisms naturally decline and our ability to convert the ubiquinone form of CoQ10 into ubiquinol diminishes. This, along with environmental and lifestyle factors, can elevate oxidative stress.

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Oxidative stress — characterized by an imbalance between free radical molecules and protective antioxidants — can damage healthy cells and mitochondria within the body. The corresponding decline in cellular function and mitochondrial integrity can impact bodily organs and systems, leading to common age-related conditions.

Free radicals react with LDL cholesterol in the blood, leading to the formation of oxidized LDL, which triggers an inflammatory response in endothelial cells, causing dysfunction and contributing to plaque buildup, which restricts blood flow in vessels.

Supplementation with Kaneka Ubiquinol® promotes cardiovascular health by supporting cellular energy production and providing antioxidant protection.

Kaneka Ubiquinol®

A Premium Heart Health Supplement Ingredient

The world’s first Ubiquinol available as a nutritional supplement ingredient

Backed by over 85 human clinical studies

Bioidentical to naturally occurring Ubiquinol

2x better absorbed than conventional CoQ102

5x-8x increase in Ubiquinol levels compared to baseline in healthy adults taking 200 mg for at least 30 days3

Requires no conversion in the body to perform antioxidant functions, unlike conventional CoQ104

Backed by Over 85 Human Clinical Studies

Research has found that Ubiquinol offers heart benefits by protecting LDL cholesterol from oxidation,5-7 which helps to maintain healthy blood flow, and by improving certain blood markers associated with heart health. Here’s how Ubiquinol helps the heart:

  • Supporting the high-energy requirements of the heart8
  • Protecting cells from damage caused by oxidative stress8-10
  • Replenishing CoQ10 blood levels depleted by statin medications11,12
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  1. Martini FH. Muscle tissue. In: Fundamentals of Anatomy and Physiology, Prentice Hall, Inc, Upper Saddle River, New Jersey, 12th edition.
  2. Langsjoen PH, Langsjoen AM. Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev. 2014; 3(1):13-17.
  3. Hosoe K, Kitano M, Kishida H, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb; 47(1):19-28.
  4. Kubo H, Yamamoto Y, Fujisawa A. Orally ingested ubiquinol-10 or ubiquinone-10 reaches the intestinal tract and is absorbed by the small intestine of mice mostly in its original form. J Clin Biochem Nutr. 2023 Mar; 72(2):101-106.
  5. Alleva R, Tomasetti M, Bompadre S, Littarru GP. Oxidation of LDL and their subfractions: kinetic aspects and CoQ10 content. Mol Aspects Med. 1997;18 Suppl:S105-12.
  6. Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta. 1992 Jun 26;1126(3):247-54.
  7. Sabbatinelli J, Orlando P, Galeazzi R, et al. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial. Nutrients. 2020;12(4):1098.
  8. Becker WM, Deamer DW. Energy from Chemical Bonds: The aerobic mode. In: The World of the Cell, 2nd Ed. The Benjamin/Cummings Series in the Life Sciences. 1991.
  9. Ernster L, Forsmark-Andrée P. Ubiquinol: an endogenous antioxidant in aerobic organisms. J Clin Invest. 1993; 71(8 Suppl):S60-5.
  10. Forsmark-Andrée P, Lee CP, Dallner, et al. Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles. Free Radic Biol Med. 1997; 22(3):391-400.
  11. Zlatohlavek L, Vrablik M, Grauova B, et al. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012; 33 Suppl 2:98-101.
  12. Fedacko J, Pella D, Fedackova P, et al. Coenzyme Q(10) and selenium in statin-associated myopathy treatment. Can J Physiol Pharmacol. 2013 Feb; 91(2):165-70.

These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.