Kaneka Ubiquinol preconception health icon

Promoting
Preconception Health

Potent Antioxidant Support for Reproductive Wellness

Ubiquinol, the active antioxidant form of Coenzyme Q10 (CoQ10 or ubiquinone), is found throughout our cells, tissues, and organs. It is required for 95% of cellular energy (ATP) production1 and is essential for healthy cellular function, aiding physiological processes vital for reproduction.

With age, naturally occurring ubiquinol levels and antioxidant mechanisms in the body naturally decline. Also, the body’s ability to convert the ubiquinone form of CoQ10 into ubiquinol diminishes. This, along with environmental and lifestyle factors, can elevate oxidative stress and impact fertility.

Oxidative stress — characterized by an imbalance between free radical molecules and protective antioxidants — is linked to declines in sperm health, ovum quality, oocyte quantity and function, and, especially in women 35 and older, ovarian reserve.2,3

Supplementation with Kaneka Ubiquinol® promotes cellular health and provides strong antioxidant support to neutralize oxidative stress that can affect sperm and egg quality.

Kaneka Ubiquinol®

A Premium Preconception Supplement Ingredient

The world’s first Ubiquinol available as a nutritional supplement ingredient

Backed by over 85 human
clinical studies

Bioidentical to naturally occurring Ubiquinol

2x better absorbed than conventional CoQ104

5x-8x increase in Ubiquinol levels compared to baseline in healthy adults taking 200 mg for at least 30 days5

Requires no conversion in the body to perform antioxidant functions, unlike conventional CoQ106

Facilitating Antioxidant Protection and Cellular Energy Production

As the most abundant lipid-soluble antioxidant in the body, ubiquinol is concentrated in the mitochondria, where most free radicals are formed, making it ideal to combat oxidative stress. Ubiquinol also supports cellular energy production, a crucial factor for sperm motility and oocyte quality, which may be compromised in older individuals having trouble conceiving.

Supporting Female Preconception Health

As women age, the quality and function of oocytes decline significantly due to oxidative stress and other physiological and environmental factors. Oxidative stress can also have detrimental effects on follicles and mitochondria, which are vital for oocyte protection and healthy maturation.7,8 The high energy demands of oocytes make them particularly reliant on efficient mitochondrial function. Damaged mitochondria can further amplify oxidative stress, creating a cycle that degrades cell function and can impact fertility.9

As a lipid-soluble antioxidant, ubiquinol reduces free radicals and protects against oxidative stress. It promotes female reproductive health by supporting:

  • Healthy mitochondrial function, which is essential for egg health
  • Mitochondrial synthesis of energy vital for oocyte health
  • Cellular energy production essential for healthy egg and embryo function
  • Mitigation of excess reactive oxygen species (ROS), protecting reproductive cells from oxidative stress

Shown to Promote Male Preconception Health

Studies reveal that Ubiquinol neutralizes oxidative stress caused by free radicals, which can detrimentally impact male fertility.10,11 Acting as an antioxidant, Kaneka Ubiquinol® supplementation protects against cellular damage and promotes sperm health.

  • In an open-label study, sperm motility improved up to 26%10
  • In an open-label study, sperm counts increased up to 53%10
  • Research also reveals improvements in sperm morphology up to 19%11

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Choose Kaneka Ubiquinol® for High-Quality Preconception Supplements

With a reputation for setting the industry standard, Kaneka supports preconception supplement manufacturers with the quality supplement ingredient they need to offer consumers the preconception supplements they are seeking.

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1. Martini FH. Muscle tissue. In: Fundamentals of Anatomy and Physiology, Prentice Hall, Inc, Upper Saddle River, New Jersey, 12th edition.
2. Kaltsas A. Oxidative Stress and Male Infertility: The Protective Role of Antioxidants. Medicina (Kaunas). 2023 Oct 4;59(10):1769.
3. Xu Y, Nisenblat, V, Lu, C, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018;16(1):29.
4. Langsjoen PH, Langsjoen AM. Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev. 2014; 3(1):13-17.
5. Hosoe K, Kitano M, Kishida H, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb; 47(1):19-28.
6. Kubo H, Yamamoto Y, Fujisawa A. Orally ingested ubiquinol-10 or ubiquinone-10 reaches the intestinal tract and is absorbed by the small intestine of mice mostly in its original form. J Clin Biochem Nutr. 2023 Mar; 72(2):101-106.
7. Bentov Y, Casper RF. The aging oocyte—can mitochondrial function be improved? Fertil Steril. 2013 Jan; 99(1):18-22.
8. Zhu Z, Xu W, Liu L. Ovarian aging: mechanisms and intervention strategies. Medical Review. 2022 Nov; 2(6):590–610.
9. Agarwal A, Aponte-Mellado A, Premkumar BJ, et al. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012 Jun 29;10:49.
10. Thakur AS, Litarru GP, Funahashi I, et al. Effect of Ubiquinol therapy on sperm parameters and serum testosterone levels in Oligoasthenozoospermic infertile men. J Clin Diagn Res. 2015; 9(9):BC01-BC03.
11. Cakiroglu B, Eyyupoglu SE, Gozukucuk R, Uyanik BS. Ubiquinol effect on sperm parameters in subfertile men who have astheno-teratozoospermia with normal sperm concentration. Nephro Urol Mon. 2014; 6(3):e16870.

These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.