Kaneka Ubiquinol logo

Supporting Women’s

Health Across Life Stages

Kaneka Ubiquinol logo

Supporting Women’s

Health Across Life Stages

Kaneka Ubiquinol logo

Supporting Women’s

Health Across Life Stages

Antioxidant Protection for Women’s Health

Ubiquinol, the active antioxidant form of coenzyme Q10 (CoQ10 or ubiquinone), is found throughout our cells, tissues, and organs. It is required for 95% of cellular energy (ATP) production1 and is essential for proper cellular function and the body’s antioxidant defense system, aiding physiological processes vital for women’s health across adulthood.

With age, our ubiquinol levels and antioxidant mechanisms naturally decline, and our ability to convert the ubiquinone form of CoQ10 into ubiquinol diminishes. This, along with environmental and lifestyle factors, can elevate oxidative stress.

Three adult women sitting on a boat within a harbor with their legs hanging off the boat side kicking the water playfully.

Oxidative stress, characterized by an imbalance between free radical molecules and protective antioxidants, can damage cell components, affecting mitochondrial and cellular function. Over time, the corresponding decline in cellular function and mitochondrial integrity can impact bodily organs and systems, leading to conditions commonly associated with aging.2

Supplementation with Kaneka Ubiquinol® promotes women’s health by supporting cellular energy production and providing antioxidant protection. For those already using women’s wellness supplements containing CoQ10, switching to Kaneka Ubiquinol® offers enhanced absorption and bioavailability.

Kaneka Ubiquinol®

A foundational ingredient for women’s wellness supplements

The world’s first Ubiquinol available as a nutritional supplement ingredient

Bioidentical to naturally occurring Ubiquinol

2x better absorbed than conventional CoQ103

5x-8x increase in Ubiquinol levels compared to baseline in healthy adults taking 200 mg for at least 30 days4

Requires no conversion in the body to perform antioxidant functions, unlike conventional CoQ105

Ubiquinol and Women's Wellness: Supporting Mitochondrial Health - Infographic
View the Infographic

Mitochondrial Health, Oxidative Stress, and Women’s Health

Women experience shifting cellular demands and increased oxidative stress related to reproductive biology, hormonal cycles, and menopause. The response of mitochondria during these stages affects overall health:

  • Estrogen decline during menopause is associated with increased oxidative stress.6
  • Chronic oxidative stress can impact mitochondrial efficiency and cellular energy output.7
  • Changes in mitochondrial function and oxidative balance may influence cardiovascular health.8,9

Supporting Female
Preconception Health

With age, the quality and function of oocytes (immature eggs) decline significantly due to oxidative stress and other physiological and environmental factors. As a lipid-soluble antioxidant, ubiquinol reduces free radicals and protects oocytes and eggs against oxidative stress. It supports reproductive wellness by aiding:

  • Healthy mitochondrial function, which is essential for oocyte and egg health10
  • Mitochondrial synthesis of energy vital for oocyte and egg health and function
  • Mitigation of excess reactive oxygen species (ROS), protecting reproductive cells from oxidative stress

Promoting Healthy Aging and
General Wellness

Through its antioxidant properties, ubiquinol helps maintain mitochondrial health and proper function, which are vital for healthy aging. Supplementation with Kaneka Ubiquinol® has been shown to increase plasma ubiquinol levels.11 A healthy ubiquinol/CoQ10 balance in the blood is associated with:

  • Cardiovascular health11
  • Muscle health12
  • Physical functioning in older adults12,13

Promoting Cardiovascular Health

Research has found that Kaneka Ubiquinol® benefits cardiovascular health by facilitating proper vasodilation, enhancing nitric oxide production, and protecting LDL cholesterol from oxidation.11 Supplementation supports healthy ubiquinol levels,11 which are associated with favorable cardiovascular biomarkers.14-17 Ubiquinol is also known to:

  • Support the high energy requirements of the heart1
  • Protect cells from damage caused by oxidative stress1,18,19
  • Replenish CoQ10 blood levels depleted by statin cholesterol medicines20

Supporting Menopausal and Postmenopausal Well-Being

Kaneka Ubiquinol® supports general health and well-being during and after menopause.

In a consumer use study, 80% of menopausal women taking 200 mg of Kaneka Ubiquinol® per day reported decreased irritability, sensitivity, stress, and mood swings after 60 days of supplementation.21

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Choose Kaneka Ubiquinol® for High-Quality Women’s Health Supplements

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1. Martini FH. Muscle tissue. In: Fundamentals of Anatomy and Physiology. 12th ed. Upper Saddle River, NJ: Prentice Hall; 2024:81-2,943-50.
2. Bratic A, Larsson NG. The role of mitochondria in aging. J Clin Invest. 2013;123(3):951-7.
3. Langsjoen PH, Langsjoen AM. Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev. 2014;3(1):13-7.
4. Hosoe K, Kitano M, Kishida H, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007;47(1):19-28.
5. Kubo H, Yamamoto Y, Fujisawa A. Orally ingested ubiquinol-10 or ubiquinone-10 reaches the intestinal tract and is absorbed by the small intestine of mice mostly in its original form. J Clin Biochem Nutr. 2023;72(2):101-6.
6. Doshi SB, Agarwal A. The role of oxidative stress in menopause. J Midlife Health. 2013 Jul;4(3):140-6.
7. Zhu Z, Xu W, Liu L. Ovarian aging: mechanisms and intervention strategies. Medical Review. 2022;2(6):590–610.
8. Zhao Y, Vanhoutte PM, Leung SW. Vascular nitric oxide: beyond eNOS. J Pharmacol Sci. 2015;129(2):83-94.
9. Lima T, Li TY, Mottis A, Auwerx J. Pleiotropic effects of mitochondria in aging. Nat Aging. 2022;2(3):199–213.
10. Mihalas BP, Redgrove KA, McLaughlin EA, Nixon B. Molecular mechanisms responsible for increased vulnerability of the ageing oocyte to oxidative damage. Oxid Med Cell Longev. 2017;4015874.
11. Sabbatinelli J, Orlando P, Galeazzi R, et al. Ubiquinol ameliorates endothelial dysfunction in subjects with mild-to-moderate dyslipidemia: a randomized clinical trial. Nutrients. 2020;12(4):1098.
12. Fischer A, Onur S, Niklowitz P, et al. Coenzyme Q10 status as a determinant of muscular strength in two independent cohorts. PLoS One. 2016;11(12):e0167124.
13. de la Bella-Garzón R, Fernández-Portero C, Alarcón D, et al. Levels of plasma coenzyme Q10 are associated with physical capacity and cardiovascular risk in the elderly. Antioxidants (Basel). 2022;11(2):279.
14. Lee DS, Evans JC, Robins SJ, et al. Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2007;27(1):127-33.
15. Dhingra R, Gona P, Wang TJ, et al. Serum gamma glutamyl transferase and risk of heart failure in the community. Arterioscler Thromb Vasc Biol. 2010;30(9):1855-60.
16. Onur S, Niklowitz P, Jacobs G, et al. Ubiquinol reduces gamma glutamyl transferase as a marker of oxidative stress in humans. BMC Res Notes. 2014;7:427.
17. Onur S, Niklowitz P, Jacobs G, et al. Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, in healthy elderly subjects. Biofactors. 2015;41(1):35-43.
18. Ernster L, Forsmark-Andrée P. Ubiquinol: an endogenous antioxidant in aerobic organisms. J Clin Invest. 1993;71(8):S60-5.
19. Forsmark-Andrée P, Lee CP, Dallner G, Ernster L. Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles. Free Radic Biol Med. 1997;22(3):391-400.
20. Zlatohlavek L, Vrablik M, Grauova B, Motykova E, Ceska R. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33(Suppl 2):98-101.
21. Kaneka Internal Report. Real-life ubiquinol study on 200 postmenopausal women. Expansion Consulteam. 2024.

These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.