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Kaneka Ubiquinol logo
Kaneka Ubiquinol logo

Supporting
Mitochondrial Health
Formulations

Supporting Sports
Nutrition Formulations

Supporting Sports
Nutrition Formulations

Partner With Kaneka Nutrients for Mitochondrial Health Formulations

Ubiquinol supports mitochondrial efficiency by enabling efficient electron transfer during mitochondrial energy production and by helping protect mitochondria from oxidative stress.

Ubiquinone and ubiquinol are two forms of coenzyme Q10 (CoQ10) that form a lipid-soluble redox pair within the mitochondrial membrane, where energy production takes place and reactive oxygen species (ROS) are generated as byproducts of energy metabolism. Through redox cycling between these two forms, CoQ10 supports efficient electron transfer within the mitochondrial electron transport chain (ETC).1,2 Ubiquinol, the reduced and active antioxidant form, plays a protective role by neutralizing ROS at the source.

Ubiquinol is found throughout our cells, tissues, and organs. It plays a critical role in mitochondrial processes responsible for approximately 95% of cellular energy production1 and supports proper cellular function and the body’s antioxidant defense system, aiding physiological processes involved in energy metabolism and cellular wellness.

How Mitochondrial Integrity Affects Systemic Wellness

Mitochondria are increasingly understood as central to systemic wellness and healthy aging, helping to coordinate processes such as immune response, signaling, and cellular repair.7,8

Beyond their role in producing adenosine triphosphate (ATP)—the energy molecule of the cell—mitochondria are now recognized for their contribution to broader cellular processes that support overall health, such as:

Mitochondrial health booklet by Kaneka Nutrients
  • Cell signaling pathways
  • Mitochondrial biogenesis
  • Mitochondrial fission and fusion
  • Programmed cell death (apoptosis) and mitophagy
  • Cell senescence9

Kaneka Ubiquinol®
A Foundational Ingredient for Mitochondrial Health Supplements

The world’s first Ubiquinol available as a nutritional supplement ingredient

Backed by over 85 human
clinical studies

Bioidentical to naturally occurring ubiquinol

2x better absorbed than conventional CoQ103

Requires no conversion in the body to perform antioxidant functions, unlike conventional CoQ104,5

Research demonstrates that 200 mg of Kaneka Ubiquinol® increases ubiquinol levels by approximately 8x compared to baseline in healthy adults when taken daily for at least 30 days6

How Oxidative Stress Affects Mitochondrial Health

Oxidative stress, which occurs when ROS levels exceed the body’s capacity for antioxidant defense, can affect mitochondrial components if left unchecked. This includes membrane lipids, proteins, cellular and mitochondrial DNA, and mitochondrial structures and functions involved in energy production.2 Over time, the corresponding influence on cellular function and mitochondrial efficiency can affect bodily organs and systems, leading to conditions commonly associated with aging.10,11

As a lipid-soluble antioxidant, ubiquinol is located within the mitochondrial membrane, where it supports cellular energy generation and neutralizes ROS where they are made. However, with age, our ubiquinol levels and antioxidant mechanisms naturally decline, and our ability to convert the ubiquinone form of CoQ10 into ubiquinol diminishes. This, along with environmental and lifestyle factors, can elevate oxidative stress.

Abstract representation of a mitochondrion surrounded by reactive oxygen species

Why Kaneka Ubiquinol® Is Preferred by Brands

Kaneka Nutrients’ evidence-based approach and our proprietary CoQ10 knowledge make Kaneka Ubiquinol® the ingredient of choice to support mitochondrial wellness across the adult lifespan:

  • Healthy aging
  • Cardiovascular health
  • Preconception wellness
  • Menopausal well-being
  • Women’s wellness
  • Sports nutrition

For those already using mitochondrial wellness supplements containing CoQ10, switching to Kaneka Ubiquinol® offers enhanced absorption and bioavailability.

Kaneka Ubiquinol® Formats

  • Softgels
  • Gummies
  • Cap-within-cap
  • Liposomal formulations
  • Liquid capsules
  • Other light- and oxygen-controlled environments

Kaneka Ubiquinol® is also available in an air-stable form as Kaneka Q30™, a 30% Ubiquinol powder.

Additional product applications include:

  • Stick packs
  • Sachets
  • Soft chews

Related Posts

Supporting Mitochondrial Health with Ubiquinol as the Foundation of Cellular Wellness

The Importance of Mitochondrial Function in Cardiovascular Health

The Power of Kaneka Ubiquinol® in Women’s Mitochondrial Health

Partner With Kaneka Nutrients for Mitochondrial Health Formulations

Kaneka Nutrients supports brands and distributors developing Ubiquinol formulations, providing scientific expertise, formulation guidance, and quality-focused manufacturing standards.

Partner With Kaneka Nutrients

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  1. Martini FH. Metabolism, nutrition and energetics. In: Fundamentals of Anatomy and Physiology. 12th ed. Prentice Hall; 2024:943-50.
  2. Bentinger M, Brismar K, Dallner G. The antioxidant role of coenzyme Q. Mitochondrion. 2007;7(Suppl):S41-50.
  3. Langsjoen PH, Langsjoen AM. Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev. 2014;3(1):13-7.
  4. Sabbatinelli J, Orlando P, Galeazzi R, et al. Ubiquinol ameliorates endothelial dysfunction in subjects with mild-to-moderate dyslipidemia: a randomized clinical trial. Nutrients. 2020;12(4):1098.
  5. Kubo H, Yamamoto Y, Fujisawa A. Orally ingested ubiquinol-10 or ubiquinone-10 reaches the intestinal tract and is absorbed by the small intestine of mice mostly in its original form. J Clin Biochem Nutr. 2023;72(2):101-6.
  6. Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007;47(1):19-28.
  7. Mohanty A, Tiwari-Pandey R, Pandey NR. Mitochondria: the indispensable players in innate immunity and guardians of the inflammatory response. J Cell Commun Signal. 2019;13(3):303-18.
  8. Picard M, Shirihai OS. Mitochondrial signal transduction. Cell Metab. 2022;34(11):1620-53.
  9. Lee-Glover LP, Picard M, Shutt TE. Mitochondria—the CEO of the cell. J Cell Sci. 2025;138(9):jcs263403.
  10. Navas P, Villalba JM, de Cabo R. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion. 2007;7(Suppl):S34-40.
  11. Bratic A, Larsson NG. The role of mitochondria in aging. J Clin Invest. 2013;123(3):951-7.

These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.